Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199048
Type: Artigo de periódico
Title: Coordinated And Circumlocutory Semantic Naming Errors Are Related To Anterolateral Temporal Lobes In Mild Ad, Amnestic Mild Cognitive Impairment, And Normal Aging.
Author: Balthazar, Marcio Luiz Figueredo
Yasuda, Clarissa Lin
Pereira, Fabrício Ramos Silvestre
Bergo, Felipe Paulo Guazzi
Cendes, Fernando
Damasceno, Benito Pereira
Abstract: Naming difficulties are characteristic of Alzheimer's disease (AD) and, to a lesser extent, of amnestic mild cognitive impairment (aMCI) patients. The association of naming impairment with anterior temporal lobe (ATL) atrophy in Semantic Dementia (SD) could be a tip of the iceberg effect, in which case the atrophy is a marker of more generalized temporal lobe pathology. Alternatively, it could reflect the existence of a functional gradient within the temporal lobes, wherein more anterior regions provide the basis for greater specificity of representation. We tested these two hypotheses in a study of 15 subjects with mild AD, 17 with aMCI, and 16 aged control subjects and showed that coordinate and circumlocutory semantic error production on the Boston Naming Test was weakly correlated with ATL gray matter density, as determined by voxel-based morphometry. Additionally, we investigated whether these errors were benefited by phonemic cues, and similarly to SD, our AD patients had small improvement. Because there is minimal gradient of temporal lobe atrophy in AD or MCI, and, therefore, no basis for a tip of the iceberg effect, these findings support the theory of a modest functional gradient in the temporal lobes, with the ATLs being involved in the naming of more specific objects.
Subject: Aged
Aged, 80 And Over
Alzheimer Disease
Amnesia
Cognition Disorders
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Names
Neuropsychological Tests
Semantics
Statistics As Topic
Temporal Lobe
Citation: Journal Of The International Neuropsychological Society : Jins. v. 16, n. 6, p. 1099-107, 2010-Nov.
Rights: fechado
Identifier DOI: 10.1017/S1355617710000998
Address: http://www.ncbi.nlm.nih.gov/pubmed/20887649
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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