Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199004
Type: Artigo de periódico
Title: Fiber Type Composition Of The Sternomastoid And Diaphragm Muscles Of Dystrophin-deficient Mdx Mice.
Author: Guido, Anderson Neri
Campos, Gerson Eduardo Rocha
Neto, Humberto Santo
Marques, Maria Julia
Minatel, Elaine
Abstract: The muscle fiber phenotype is mainly determined by motoneuron innervation and changes in neuromuscular interaction alter the muscle fiber type. In dystrophin-deficient mdx mice, changes in the molecular assembly of the neuromuscular junction and in nerve terminal sprouting occur in the sternomastoid (STN) muscle during early stages of the disease. In this study, we were interested to see whether early changes in neuromuscular assembly are correlated with alterations in fiber type in dystrophic STN at 2 months of age. A predominance of hybrid fast myofibers (about 52% type IIDB) was observed in control (C57Bl/10) STN. In mdx muscle, the lack of dystrophin did not change this profile (about 54% hybrid type IIDB). Pure fast type IID fibers predominated in normal and dystrophic diaphragm (DIA; about 39% in control and 30% in mdx muscle) and a population of slow Type I fibers was also present (about 10% in control and 13% in mdx muscle). In conclusion, early changes in neuromuscular assembly do not affect the fiber type composition of dystrophic STN. In contrast to the pure fast fibers of the more affected DIA, the hybrid phenotype of the STN may permit dynamic adaptations during progression of the disease.
Subject: Adaptation, Physiological
Adenosine Triphosphatases
Animals
Diaphragm
Dystrophin
Male
Mice
Mice, Inbred C57bl
Mice, Knockout
Muscle Fibers, Fast-twitch
Muscle Fibers, Slow-twitch
Rights: fechado
Identifier DOI: 10.1002/ar.21224
Address: http://www.ncbi.nlm.nih.gov/pubmed/20730859
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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