Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198967
Type: Artigo de periódico
Title: Retinyl Palmitate Flexible Polymeric Nanocapsules: Characterization And Permeation Studies.
Author: Teixeira, Zaine
Zanchetta, Beatriz
Melo, Bruna A G
Oliveira, Luciana L
Santana, Maria H A
Paredes-Gamero, Edgar J
Justo, Giselle Z
Nader, Helena B
Guterres, Sílvia S
Durán, Nelson
Abstract: Polymeric nanocapsules with elastic characteristics were prepared by the pre-formed polymer interfacial deposition method. The system consists of an oily core of retinyl palmitate with Span 60 and a polymeric wall of poly(D,L-lactide) (PLA). A narrow size distribution (215 nm, P.D.I. 0.10) was showed by dynamic light scattering (DLS) analyses. Particle deformability was observed by transmission electron microscopy (TEM) images and permeation of the particles through two superposed membranes of smaller pore diameters. Permeation studies were achieved using plastic surgery abdominal human skin by Franz diffusion cell. Retinyl palmitate permeates into deep skin layers. Besides, a PLA fluorescent derivative conjugated with Nile blue dye by an amide covalent bound was additionally obtained. Permeation profile of the nanocapsules with the fluorescent polymer was evaluated by confocal laser scanning microscopy (CLSM). The CLSM showed that nanocapsules were distributed uniformly, suggesting that the permeation mechanism through skin is intercellular. Thus, the use of these nanocapsules may be a feasible strategy to enhance the permeation of actives into the skin when delivery to deep layers is aimed.
Subject: Capsules
Chromatography, High Pressure Liquid
Drug Carriers
Elasticity
Humans
Microscopy, Confocal
Microscopy, Electron, Transmission
Nanocapsules
Particle Size
Polyesters
Polymers
Skin
Skin Absorption
Vitamin A
Vitamins
Rights: fechado
Identifier DOI: 10.1016/j.colsurfb.2010.06.016
Address: http://www.ncbi.nlm.nih.gov/pubmed/20655183
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_20655183.pdf703.5 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.