Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198944
Type: Artigo de periódico
Title: Peripheral Mechanisms Underlying The Essential Role Of P2x7 Receptors In The Development Of Inflammatory Hyperalgesia.
Author: Teixeira, Juliana Maia
Oliveira, Maria Cláudia G
Parada, Carlos Amílcar
Tambeli, Cláudia Herrera
Abstract: Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in inflammatory states, we hypothesized that the activation of the P2X7 receptor by endogenous ATP contributes to carrageenan-induced mechanical hyperalgesia, and that this contribution is mediated by an indirect sensitization of the primary afferent nociceptors. Co-administration of the selective P2X7 receptor antagonist, A-438079, or the P2X7 receptor antagonist, oATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan and significantly reduced the increased concentration of TNF-alpha, IL-6 and CINC-1, but not of IL-1beta induced by carrageenan in the subcutaneous tissue of the rat's hind paw. We concluded that the activation of P2X7 receptors by endogenous ATP is essential to the development of the mechanical hyperalgesia induced by carrageenan in the subcutaneous tissue. It is suggested that this essential role of P2X7 receptors in the development of carrageenan-induced mechanical hyperalgesia is mediated by an indirect sensitization of the primary afferent nociceptors dependent on the previous release of TNF-alpha, IL-6 and CINC-1, but not of IL-1beta.
Subject: Adenosine Triphosphate
Animals
Carrageenan
Chemokine Cxcl1
Disease Models, Animal
Hyperalgesia
Inflammation
Interleukin-6
Male
Pyridines
Rats
Rats, Wistar
Receptors, Purinergic P2x7
Tetrazoles
Tumor Necrosis Factor-alpha
Citation: European Journal Of Pharmacology. v. 644, n. 1-3, p. 55-60, 2010-Oct.
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2010.06.061
Address: http://www.ncbi.nlm.nih.gov/pubmed/20621090
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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