Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198912
Type: Artigo de periódico
Title: Effects Of Gestational And Lactational Fenvalerate Exposure On Immune And Reproductive Systems Of Male Rats.
Author: Nassr, Azize C C
Arena, Arielle C
Toledo, Fabiola C
Bissacot, Denise Z
Fernandez, Carla D B
Spinardi-Barbisan, Ana Lúcia T
Pires, Paulo W
Kempinas, Wilma G
Abstract: The aim of this study was to determine the consequent reproductive developmental and immunotoxic effects due to exposure to fenvalerate during pregnancy and lactation in male offspring of maternal-treated rats. Pregnant rats were treated daily by oral gavage with 40 or 80 mg/kg of fenvalerate or corn oil (vehicle, control), from d 12 of pregnancy to d 21 of lactation. Immune and reproductive developmental effects were assessed in male offspring at postnatal days (PND) 40 (peripuberty), 60 (postpuberty), and 90 (sexual maturity). Treatment with the higher dose (80 mg/kg) resulted in convulsive behavior, hyperexcitability, and mortality in 45% of the dams. Fenvalerate was detected in the fetus due to placental transfer, as well as in pups due to breast-milk ingestion, persisting in male offspring until PND 40 even though pesticide treatment was terminated on PND 20. However, fenvalerate did not produce marked alterations in age of testicular descent to the scrotum and prepucial separation, parameters indicative of puberty initiation. In contrast, at puberty, there was a reduction in testicular weight and sperm production in male offspring of maternal-treated rats. At adulthood, the sperm counts and fertility did not differ between control and treated groups. Testosterone levels were not changed at any time during reproductive development. Similarly, no apparent exposure-related effects were detected in the histological structures of the lymphohematopoietic system. Data indicate that fenvalerate, in this experimental model, interfered with initial development of the male reproductive system, but that these effects on sperm production or fertility did not persist into adulthood. There was no apparent evidence that fenvalerate altered testosterone levels or produced a disruption in male endocrine functions.
Subject: Animals
Animals, Suckling
Bone Marrow
Female
Infertility, Male
Lymphoid Tissue
Male
Maternal Exposure
Milk
Nitriles
Pesticides
Pregnancy
Prenatal Exposure Delayed Effects
Pyrethrins
Rats
Rats, Wistar
Testis
Testosterone
Rights: fechado
Identifier DOI: 10.1080/15287391003751745
Address: http://www.ncbi.nlm.nih.gov/pubmed/20563929
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_20563929.pdf177.63 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.