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Type: Artigo de periódico
Title: Involvement Of Temporomandibular Joint P2x3 And P2x2/3 Receptors In Carrageenan-induced Inflammatory Hyperalgesia In Rats.
Author: Teixeira, Juliana Maia
Oliveira, Maria Cláudia G
Nociti, F H
Clemente-Napimoga, J T
Pelegrini-da-Silva, Adriana
Parada, Carlos Amílcar
Tambeli, Cláudia Herrera
Abstract: The aim of this study was to investigate the role of P2X3, P2X2/3 and P2X7 receptors in the development of TMJ hyperalgesia induced by carrageenan. We also investigated the expression of mRNA of P2X7 receptors in the trigeminal ganglia and the existence of functional P2X7 receptors in the rat's TMJ. The P2X1, P2X3 and P2X2/3 receptor antagonist TNP-ATP, but not the selective P2X7 receptor antagonist A-438079, significantly reduced carrageenan-induced TMJ inflammatory hyperalgesia. The qPCR assay showed that mRNA of P2X7 receptors are expressed in the trigeminal ganglia but this expression is not increased by the inflammation induced by carrageenan in the TMJ region. The P2X7 receptor agonist BzATP induced TMJ inflammatory hyperalgesia that was significantly reduced by pretreatment with dexamethasone. These results indicate that P2X3 and P2X2/3 but not P2X7 receptors are involved in carrageenan-induced TMJ inflammatory hyperalgesia. However, functional P2X7 receptors are expressed in the TMJ region. The activation of these receptors by BzATP sensitizes the primary afferent nociceptors in the TMJ through the previous release of inflammatory mediators. The findings of this study point out P2X3 and P2X2/3 receptors, but not P2X7 receptors, as potential targets for the development of new analgesic drugs to control TMJ inflammatory pain.
Subject: Adenosine Triphosphate
Purinergic P2x Receptor Agonists
Purinergic P2x Receptor Antagonists
Rna, Messenger
Rats, Wistar
Receptors, Purinergic P2
Receptors, Purinergic P2x2
Receptors, Purinergic P2x3
Receptors, Purinergic P2x7
Temporomandibular Joint
Trigeminal Ganglion
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2010.06.008
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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