Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198897
Type: Artigo de periódico
Title: Liposomal Encapsulation Improves The Duration Of Soft Tissue Anesthesia But Does Not Induce Pulpal Anesthesia.
Author: Franz-Montan, Michelle
Silva, André L R
Fraceto, Leonardo F
Volpato, Maria C
Paula, Eneida de
Ranali, José
Groppo, Francisco C
Abstract: To compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulations. Double-blinded, randomized crossover study. University ambulatory dental center. 30 ASA physical status I volunteers. Volunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal fold. Pain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded. Pulpal anesthesia was evaluated using an electric pulp tester. VAS values (median, 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 - 21) for B10, LB10, and B20, respectively. No differences were noted among the groups (Friedman test; P = 0.58). Soft tissue anesthesia was also not different. The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test; P < 0.01) than the other agents [B10 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min]. None of the topical benzocaine formulations tested induced pulpal anesthesia. The encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia. However, it did not induce pulpal anesthesia.
Subject: Administration, Topical
Adolescent
Adult
Anesthesia, Dental
Anesthesia, Local
Anesthetics, Local
Benzocaine
Cross-over Studies
Dental Pulp
Double-blind Method
Female
Gels
Humans
Liposomes
Male
Mouth Mucosa
Pain Measurement
Time Factors
Young Adult
Rights: fechado
Identifier DOI: 10.1016/j.jclinane.2010.03.001
Address: http://www.ncbi.nlm.nih.gov/pubmed/20542419
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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