Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198886
Type: Artigo de periódico
Title: High-grade Transformation Of Adenoid Cystic Carcinomas: A Study Of The Expression Of Glut1 Glucose Transporter And Of Mitochondrial Antigen.
Author: Bonfitto, V L
Demasi, A P
Costa, A F
Bonfitto, J F
Araujo, V C
Altemani, A
Abstract: To broaden understanding of phenomena involved in progression from classical adenoid cystic carcinomas (ACCs) to tumours with high-grade transformation (ACC-HGT) METHODS: Expression of proteins linked to cellular metabolism as well as the microvascular density (MVD) in conventional and transformed areas were analysed. Findings were compared with ordinary ACCs. In seven cases of ACC-HGT and in 18 ACCs the expressions of GLUT1, mitochondrial antigen (MTA), CD34 (for assessing MVD), alpha-SMA and P63 (for detection of myoepithelial cells) and Ki-67 (for evaluation of proliferation index) were examined. The transformed component corresponded to adenocarcinomas with frequent (four cases) or scarce/absent (three cases) gland differentiation. In the latter, Ki-67 index was higher, two patients presented lymphatic metastasis and one died of disease. In the former, there was one long-term survivor and one with liver metastasis. Conventional areas of both ACC-HGT and ACC were negative for GLUT1 in most cases (83.3% and 81.3%, respectively) and exhibited low or no expression of MTA (100% and 66.7% of cases, respectively). In contrast, the HGT component presented increased expression of both proteins (GLUT1+ in 50% of cases; MTA+ in 100%). However, the degree of GLUT1 expression did not correlate with clinical outcome. MVD did not differ significantly between conventional and transformed components. Transformation of classical ACC into ACC-HGT encompasses adenocarcinomas with variable degrees of differentiation and seems to lead to metabolic changes without reflection in tumour vasculature. Despite the tumours' higher GLUT1 expression, this protein has no utility as a prognostic marker.
Subject: Adenocarcinoma
Adult
Aged
Autoantigens
Carcinoma, Adenoid Cystic
Cell Differentiation
Disease Progression
Female
Glucose Transporter Type 1
Humans
Male
Middle Aged
Mitochondria
Neoplasm Proteins
Neovascularization, Pathologic
Prognosis
Salivary Gland Neoplasms
Young Adult
Rights: fechado
Identifier DOI: 10.1136/jcp.2010.075390
Address: http://www.ncbi.nlm.nih.gov/pubmed/20530155
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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