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Type: Artigo de periódico
Title: Antibacterial Nitric Oxide-releasing Polyester For The Coating Of Blood-contacting Artificial Materials.
Author: Seabra, Amedea B
Martins, Dorival
Simões, Maíra M S G
da Silva, Regiane
Brocchi, Marcelo
de Oliveira, Marcelo G
Abstract: The emergence of multidrug-resistant bacteria associated with blood-contacting artificial materials is a growing health problem, which demands new approaches in the field of biomaterials research. In this study, a poly(sulfhydrylated polyester) (PSPE) was synthesized by the polyesterification reaction of mercaptosuccinic acid with 3-mercapto-1,2-propanediol and blended with poly(methyl methacrylate) (PMMA) from solution, leading to solid PSPE/PMMA films, with three different PSPE : PMMMA mass ratios. These films were subsequently S-nitrosated through the immersion in acidified nitrite solution, yielding poly(nitrosated)polyester/PMMA (PNPE/PMMA) films. A polyurethane intravascular catheter coated with PNPE/PMMA was shown to release nitric oxide (NO) in phosphate buffered saline solution (pH 7.4) at 37 degrees C at rates of 4.6 nmol/cm(2)/h in the first 6 h and 0.8 nmol/cm(2)/h in the next 12 h. When used to coat the bottom of culture plates, NO released from these films exerted a potent dose- and time-dependent antimicrobial activity against Staphylococcus aureus and a multidrug-resistant Pseudomonas aeruginosa strains. This antibacterial effect of PSPE/PMMA films opens a new perspective for the coating of blood-contacting artificial materials, for avoiding their colonization with highly resistant bacteria.
Subject: Anti-bacterial Agents
Biocompatible Materials
Catheters, Indwelling
Nitric Oxide
Polymethyl Methacrylate
Pseudomonas Aeruginosa
Staphylococcus Aureus
Sulfhydryl Compounds
Rights: fechado
Identifier DOI: 10.1111/j.1525-1594.2010.00998.x
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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