Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198852
Type: Artigo de periódico
Title: Micrornas: A New Paradigm On Molecular Urological Oncology.
Author: Reis, Leonardo Oliveira
Pereira, Tiago Campos
Lopes-Cendes, Iscia
Ferreira, Ubirajara
Abstract: MicroRNAs (miRNA) are a class of naturally occurring, small, noncoding RNAs that function as specific repressors of protein-encoding genes, being pivotal regulators of development and cellular homeostasis. They have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in different cancer types. Deregulation of these so-called cancerous miRNAs can figure prominently in tumor initiation and progression. The Human miRNA profile is under development, and it is of concern that there is so little agreement on the miRNAs found in each of the studies. Bioinformatics progress and efficient delivery are essential to overcome barriers to miRNA use in clinical practice.
Subject: Genetic Therapy
Humans
Medical Oncology
Micrornas
Prognosis
Rna, Untranslated
Urologic Neoplasms
Urology
Rights: fechado
Identifier DOI: 10.1016/j.urology.2010.03.012
Address: http://www.ncbi.nlm.nih.gov/pubmed/20472270
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_20472270.pdf348.17 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.