Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198847
Type: Artigo de periódico
Title: Cd10 (neutral Endopeptidase) Expression In Myoepithelial Cells Of Salivary Neoplasms.
Author: Neves, Catarina de Oliveira
Soares, Andresa Borges
Costa, Ana Flávia
de Araujo, Vera Cavalcanti
Furuse, Cristiane
Juliano, Priscila Bianchi
Altemani, Albina
Abstract: CD10 is a cell surface peptidase expressed in a wide variety of normal and neoplastic tissues, including breast myoepithelial cells. In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas. However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed. We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10. In salivary glands, CD10 expression was not detected in myoepithelial cells. Only fibrocytes within the intralobular stroma were CD10 positive. In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms. When the different groups of tumors were compared, epithelial-myoepithelial carcinomas (EMEC) showed a stark contrast with the others (83.3% of cases with CD10 expression). Surprisingly, adenoid cystic carcinomas and basal cell adenomas were negative in 100% of the cases. Myoepitheliomas, pleomorphic adenomas, and myoepithelial carcinomas were positive in 27.7%, 30.0%, and 40% of the cases, respectively. In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts. However, the gain of this protein is not a sensitive marker for detecting myoepithelial cells in the majority of the tumors, except for EMEC. The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.
Subject: Actins
Aged
Cell Differentiation
Cell Transformation, Neoplastic
Diagnosis, Differential
Disease Progression
Epithelial Cells
Female
Humans
Immunohistochemistry
Male
Middle Aged
Myocytes, Smooth Muscle
Myoepithelioma
Neprilysin
Salivary Gland Neoplasms
Tumor Markers, Biological
Rights: fechado
Identifier DOI: 10.1097/PAI.0b013e3181b8f7c5
Address: http://www.ncbi.nlm.nih.gov/pubmed/19752720
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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