Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198831
Type: Artigo de periódico
Title: Natural And Prosthetic Heart Valve Calcification: Morphology And Chemical Composition Characterization.
Author: Weska, Raquel F
Aimoli, Cassiano G
Nogueira, Grínia M
Leirner, Adolfo A
Maizato, Marina J S
Higa, Olga Z
Polakievicz, Bronislaw
Pitombo, Ronaldo N M
Beppu, Marisa M
Abstract: Calcification is the most common cause of damage and subsequent failure of heart valves. Although it is a common phenomenon, little is known about it, and less about the inorganic phase obtained from this type of calcification. This article describes the scanning electron microscopy (SEM)/energy dispersive X-ray spectroscopy and Ca K-edge X-ray absorption near edge structure (XANES) characterization performed in natural and bioprosthetic heart valves calcified in vivo (in comparison to in vitro-calcified valves). SEM micrographs indicated the presence of deposits of similar morphology, and XANES results indicate, at a molecular level, that the calcification mechanism of both types of valves are probably similar, resulting in formation of poorly crystalline hydroxyapatite deposits, with Ca/P ratios that increase with time, depending on the maturation state. These findings may contribute to the search for long-term efficient anticalcification treatments.
Subject: Calcinosis
Cardiomyopathies
Heart Valve Prosthesis
Heart Valves
Humans
Microscopy, Electron, Scanning
Prosthesis Failure
Spectrometry, X-ray Emission
Rights: fechado
Identifier DOI: 10.1111/j.1525-1594.2009.00858.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/20420613
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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