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Type: Artigo de periódico
Title: The Effects Of Acute Restraint Stress On Nociceptive Responses Evoked By The Injection Of Formalin Into The Temporomandibular Joint Of Female Rats.
Author: Botelho, Ana Paula
Gameiro, Gustavo Hauber
Tuma, Carlos Eduardo da Silva Nossa
Marcondes, Fernanda Klein
de Arruda Veiga, Maria Cecília Ferraz
Abstract: The temporomandibular joint (TMJ) formalin test was used to evaluate the effects of acute restraint stress on the nociceptive behavioral responses of female rats during proestrus and estrus phases of the estrous cycle. Rats were subjected to one session of restraint stress (15, 30 min or 1 h). They were then either immediately killed to allow the collection of blood for hormonal radioimmunoassay determinations or subjected to TMJ formalin test to evaluate nociception. All stress protocols significantly raised the plasma concentrations of corticosterone. The performance of rats subjected to 15 and 30 min of restraint stress was similar to that of control rats, whereas rats that were stressed for 1 h showed a decrease in nociceptive responses, during both proestrus and estrus phases. The stress-induced analgesia (SIA) was greater in the proestrus phase. To evaluate the role of kappa-opioid receptors, the selective receptor kappa-opioid antagonist nor-binaltorphimine (nor-BNI; 200 microg or saline) was injected into the TMJ 24 h prior to the 1 h stress period and the TMJ formalin test. The local administration of nor-BNI partially reversed the SIA during the proestrus phase. These findings suggest that (1) acute stress for 1 h can produce analgesia both during proestrus and estrus phases; this effect is greater during the proestrus phase and (2) kappa-opioid receptor activation is involved in the SIA observed in the proestrus phase.
Subject: Acute Disease
Behavior, Animal
Narcotic Antagonists
Pain Measurement
Rats, Wistar
Receptors, Opioid
Restraint, Physical
Stress, Physiological
Temporomandibular Joint
Temporomandibular Joint Disorders
Citation: Stress (amsterdam, Netherlands). v. 13, n. 3, p. 269-75, 2010-May.
Rights: fechado
Identifier DOI: 10.3109/10253890903362645
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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