Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198709
Type: Artigo de periódico
Title: Anti-ulcerogenic Effect Of A Whey Protein Isolate And Collagen Hydrolysates Against Ethanol Ulcerative Lesions On Oral Administration To Rats.
Author: Castro, G A
Carvalho, J E
Tinti, S V
Possenti, A
Sgarbieri, V C
Abstract: The effect of the administration of a whey protein isolate (WPI) and collagen hydrolysates on ethanol-induced ulcerative lesions was studied in rats. WPI and bovine or porcine collagen hydrolysate (BCH and PCH, respectively) were given to rats by gavage. In acute experiments, (single-dose) physiological saline (10 mL/kg of body weight) was used as the negative control, and carbenoxolone (200 mg/kg of body weight) was used as a positive control. Ethanol (1 mL per 250-g rat) was also given by gavage. These treatments reduced the ulcerative lesion index (ULI) in a range of 40-77%, depending on the dosage. Some mixtures of WPI with either PCH or BCH provided results that suggested synergisms between WPI and the collagen hydrolysates. For example, WPI/BCH (in the proportion of 375:375 mg/kg of body weight) decreased ULI by 64%. The mechanism for mucosal protection involved a decrease in plasma gastrin (approximately 40%), a significant increase (50-267%) in mucus production, and a reduction in ULI (percentage) when intragastric administrations were performed after in vivo alkylation by N-ethylmaleimide. Results suggest that gastrin, sulfhydryl substances, and some mechanisms related to mucus production are all involved in gastric ulcer protection against ethanol. The collagen hydrolysates (both PCH and BCH) presented a stronger effect on mucus production; on the other hand, the effect of WPI was also dependent on sulfhydryl compounds, resulting in a more protective effect when the two proteins were administered together.
Subject: Alkylation
Animals
Anti-ulcer Agents
Carbenoxolone
Cattle
Collagen
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Ethanol
Ethylmaleimide
Gastric Mucosa
Gastrins
Hydrolysis
Male
Milk Proteins
Mucus
Rats
Rats, Wistar
Stomach
Stomach Ulcer
Sulfhydryl Compounds
Swine
Rights: fechado
Identifier DOI: 10.1089/jmf.2008.0277
Address: http://www.ncbi.nlm.nih.gov/pubmed/20136440
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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