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Type: Artigo de periódico
Title: Analysis Of The Histologic Features In The Differential Diagnosis Of Intrahepatic Neonatal Cholestasis.
Author: Bellomo-Brandao, Maria Angela
Escanhoela, Cecilia A F
Meirelles, Luciana R
Porta, Gilda
Hessel, Gabriel
Abstract: To compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. Liver biopsies from 86 infants with IHNC were evaluated. The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life. The following histologic features were evaluated: cholestasis, eosinophilia, giant cells, erythropoiesis, siderosis, portal fibrosis, and the presence of a septum. Based on the diagnosis, patients were classified into three groups: group 1 (infectious; n=18), group 2 (genetic-endocrine-metabolic; n=18), and group 3 (idiopathic; n=50). There were no significant differences with respect to the following variables: cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and presence of a septum. A significant difference was observed with respect to erythropoiesis, which was more severe in group 1 (Fisher's exact test, P=0.016). A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum.
Subject: Biopsy
Cholestasis, Intrahepatic
Diagnosis, Differential
Infant, Newborn
Citation: World Journal Of Gastroenterology : Wjg. v. 15, n. 4, p. 478-83, 2009-Jan.
Rights: aberto
Identifier DOI: 
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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