Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198533
Type: Artigo de periódico
Title: Central Granular Cell Odontogenic Tumor: A Histopathologic And Immunohistochemical Study.
Author: Mesquita, Ana Terezinha Marques
Santos, Cássio Roberto Rocha
Gomez, Ricardo Santiago
Jorge, Jacks
León, Jorge Esquiche
de Almeida, Oslei Paes
Abstract: The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults. We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34betaE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, beta-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype. Ki-67 labeling index was 1.8%, whereas p53 was negative. These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.
Subject: Disease-free Survival
Female
Granular Cell Tumor
Humans
Immunohistochemistry
Mandibular Neoplasms
Odontogenic Tumors
Tumor Markers, Biological
Young Adult
Rights: fechado
Identifier DOI: 10.1016/j.anndiagpath.2009.04.001
Address: http://www.ncbi.nlm.nih.gov/pubmed/19917479
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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