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dc.typeArtigo de periódicopt_BR
dc.title[erbb-2 Expression And Hormone Receptor Status In Areas Of Transition From In Situ To Invasive Ductal Breast Carcinoma].pt_BR
dc.contributor.authorPeres, Raquel Mary Rodriguespt_BR
dc.contributor.authorDerchain, Sophie Françoise Mauricettept_BR
dc.contributor.authorHeinrich, Juliana Karina Ruizpt_BR
dc.contributor.authorSerra, Kátia Pitonpt_BR
dc.contributor.authorPinto, Glauce Aparecidapt_BR
dc.contributor.authorSoares, Fernando Augustopt_BR
dc.contributor.authorSarian, Luís Otávio Zanattapt_BR
unicamp.authorRaquel Mary Rodrigues Peres, Programa de Tocoginecologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR Françoise Mauricette Derchain,pt Karina Ruiz Heinrich,ptátia Piton Serra,pt Aparecida Pinto,pt Augusto Soares,ptís Otávio Zanatta Sarian,pt
dc.subjectBreast Neoplasmspt_BR
dc.subjectCarcinoma, Ductal, Breastpt_BR
dc.subjectCarcinoma, Intraductal, Noninfiltratingpt_BR
dc.subjectCross-sectional Studiespt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectReceptor, Erbb-2pt_BR
dc.subjectReceptors, Estrogenpt_BR
dc.subjectReceptors, Progesteronept_BR
dc.description.abstractto evaluate the expression of erbB-2 and of the estrogen and progesterone (ER/P) hormonal receptors in the transition regions between the in situ and the invasive fractions of ductal breast neoplasia (ISDC and IDC, respectively). Eighty-five cases of breast neoplasia, containing contiguous ISDC and IDC areas, were selected. Histological specimens from the ISDC and the IDC areas were obtained through the tissue microarray (TMA) technique. The erbB-2 and the ER/PR expressions were evaluated through conventional immunohistochemistry. The McNemar's test was used for the comparative analysis of the expressions of erbB-2 protein and the ER/PR in the in situ and invasive regions of the tumors. The confidence intervals were set to 5% (p=0.05). Intraclass correlation coefficients (ICC) were calculated to assess the cross-tabulation agreement of the erbB-2 and the ER/PR expression in the ISDC and the IDC areas. the erbB-2 expression has not differed between the ISDC and the IDC areas (p=0.38). Comparing the two areas in each case, there was agreement in the expression of erbB-2 (ICC=0.64), PR (ICC=0.71) and ER (ICC=0.64). Restricting the analysis to tumors with the in situ component harboring necrosis (comedo), the ICC for erbB-2 was 0.4, compared to 0.6 for the whole sample. In this select group, the ICC for PR/ER did not differ substantially from those obtained with the complete dataset: as for the ER, ICC=0.7 (versus 0.7 for the entire sample) and for PR, ICC=0.7 (versus 0.6 for the entire sample). our findings suggest that the erbB-2 and the ER/PR expressions do not differ in the contiguous in situ and invasive components of breast ductal tumors.en
dc.relation.ispartofRevista Brasileira De Ginecologia E Obstetrícia : Revista Da Federação Brasileira Das Sociedades De Ginecologia E Obstetríciapt_BR
dc.relation.ispartofabbreviationRev Bras Ginecol Obstetpt_BR
dc.identifier.citationRevista Brasileira De Ginecologia E Obstetrícia : Revista Da Federação Brasileira Das Sociedades De Ginecologia E Obstetrícia. v. 31, n. 9, p. 461-7, 2009-Sep.pt_BR
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