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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFigures Of Merit In The Quantification Of Ibuprofen Enantiomers By Chiral Hplc.pt_BR
dc.contributor.authorValderrama, Patríciapt_BR
dc.contributor.authorRomero, Adriano Lopespt_BR
dc.contributor.authorImamura, Paulo Mitsuopt_BR
dc.contributor.authorPoppi, Ronei Jesuspt_BR
unicamp.authorPatrícia Valderrama, Department of Analytical Chemistry, Institute of Chemistry, University of Campinas-UNICAMP, P.O. Box 6154, 13083-970, Campinas, SP, Brazil.pt_BR
unicamp.author.externalAdriano Lopes Romero,pt
unicamp.author.externalPaulo Mitsuo Imamura,pt
unicamp.author.externalRonei Jesus Poppi,pt
dc.subjectChromatography, High Pressure Liquidpt_BR
dc.subjectIbuprofenpt_BR
dc.subjectStereoisomerismpt_BR
dc.description.abstractThe determination of ibuprofen (IBU) enantiomers by chiral high-performance liquid chromatographic is described. The methodology is based on chiral recognition of ibuprofen by a chiral column based on cellulose tris(4-methylbenzoate) coated on silica gel (Chiralcel OJ-H). The mobile phase is n-hexane-2-propanol-trifluoroacetic acid (98:2:0.1, v/v/v). The flow rate was 1.0 mL/min, and UV detection was 254 nm. The samples of ibuprofen were prepared in n-hexane in the concentration range 50-100% of (S)-IBU 1 x 10(-3) mol/L. Calibration and validation method were performed with six and nine samples, respectively. Goodness-of-fit measures represented by correlation coefficient, y-intercept, and slope of the regression line were 0.9836, 21373, 2162, respectively. Average of the relative error of the proposed method was 3.0%, 0.9% (S)-IBU selectivity, and 2162% (S)-IBU-1 sensitivity. The minimum concentration difference between two samples that could be determined in the linear dynamic range was 0.4% (S)-IBU. Limits of detection and quantification were 8.1 and 27.0% (S)-IBU, respectively. These results indicate that the proposed method can be employed for determination of the enantiomeric composition of IBU.en
dc.relation.ispartofJournal Of Chromatographic Sciencept_BR
dc.relation.ispartofabbreviationJ Chromatogr Scipt_BR
dc.date.issued2009-Octpt_BR
dc.identifier.citationJournal Of Chromatographic Science. v. 47, n. 9, p. 777-80, 2009-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume47pt_BR
dc.description.firstpage777-80pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1945-239Xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19835687pt_BR
dc.date.available2015-11-27T13:15:36Z-
dc.date.accessioned2015-11-27T13:15:36Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:15:36Z (GMT). No. of bitstreams: 1 pmed_19835687.pdf: 142543 bytes, checksum: 9a7eb74cd91f547586d55d794d3030a2 (MD5) Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198500-
dc.identifier.idPubmed19835687pt_BR
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