Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Phylogenetic Classification Of Human Papillomavirus Genotypes In High-grade Cervical Intraepithelial Neoplasia In Women From A Densely Populated Brazilian Urban Region.
Author: Pitta, Denise Rocha
Sarian, Luis Otávio
Campos, Elisabete Aparecida
Rabelo-Santos, Sílvia Helena
Syrjänen, Kari
Derchain, Sophie Françoise
Abstract: Differences in human papillomavirus (HPV) types may correlate with the biological potential and invasion risk of high-grade cervical intraepithelial neoplasia (CIN 2 and CIN 3). The objective of this study was to determine the relationship between different combinations of HPV types and CIN severity. Cross-sectional study, at Universidade Estadual de Campinas (Unicamp). Cervical samples from 106 women treated due to CIN 2 (18) or CIN 3 (88) were examined for specific HPV genotypes using Roche Linear Array (LA-HPV). The proportions of CIN 2 and CIN 3 in groups of women infected with the HPV phylogenetic groups A7 and A9 were compared. Three groups were formed: women with single infections; multiple infections; and the whole sample. Multiple infections were detected in 68 samples (64.7%). The most frequent high-risk genotypes detected (single/multiple) were HPV 16 (57.1%), HPV 58 (24.7%), HPV 33 (15.2%), HPV 52 (13.3%), HPV 31 (10.4%), HPV 51 (7.6%) and HPV 18 (6.6%). Women without infection with HPV species Alpha 9 were less likely to have CIN 3 than were their Alpha 9 HPV-infected counterparts. HPV 16 and/or HPV 18, with or without associations with other viral types, were more frequently found in women with CIN 3 than in those with CIN 2. The severity of high-grade CIN may be aggravated by the presence of HPV types included in the Alpha 9 phylogenetic classification and by infections including HPV 16 and 18, singly or in combination with other HPV genotypes.
Subject: Adolescent
Cervical Intraepithelial Neoplasia
Dna, Viral
Epidemiologic Methods
Human Papillomavirus 16
Human Papillomavirus 18
Middle Aged
Papillomavirus Infections
Urban Population
Uterine Cervical Neoplasms
Young Adult
Citation: São Paulo Medical Journal = Revista Paulista De Medicina. v. 127, n. 3, p. 122-7, 2009.
Rights: aberto
Identifier DOI: 
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_19820871.pdf264.48 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.