Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198497
Type: Artigo de periódico
Title: Phylogenetic Classification Of Human Papillomavirus Genotypes In High-grade Cervical Intraepithelial Neoplasia In Women From A Densely Populated Brazilian Urban Region.
Author: Pitta, Denise Rocha
Sarian, Luis Otávio
Campos, Elisabete Aparecida
Rabelo-Santos, Sílvia Helena
Syrjänen, Kari
Derchain, Sophie Françoise
Abstract: Differences in human papillomavirus (HPV) types may correlate with the biological potential and invasion risk of high-grade cervical intraepithelial neoplasia (CIN 2 and CIN 3). The objective of this study was to determine the relationship between different combinations of HPV types and CIN severity. Cross-sectional study, at Universidade Estadual de Campinas (Unicamp). Cervical samples from 106 women treated due to CIN 2 (18) or CIN 3 (88) were examined for specific HPV genotypes using Roche Linear Array (LA-HPV). The proportions of CIN 2 and CIN 3 in groups of women infected with the HPV phylogenetic groups A7 and A9 were compared. Three groups were formed: women with single infections; multiple infections; and the whole sample. Multiple infections were detected in 68 samples (64.7%). The most frequent high-risk genotypes detected (single/multiple) were HPV 16 (57.1%), HPV 58 (24.7%), HPV 33 (15.2%), HPV 52 (13.3%), HPV 31 (10.4%), HPV 51 (7.6%) and HPV 18 (6.6%). Women without infection with HPV species Alpha 9 were less likely to have CIN 3 than were their Alpha 9 HPV-infected counterparts. HPV 16 and/or HPV 18, with or without associations with other viral types, were more frequently found in women with CIN 3 than in those with CIN 2. The severity of high-grade CIN may be aggravated by the presence of HPV types included in the Alpha 9 phylogenetic classification and by infections including HPV 16 and 18, singly or in combination with other HPV genotypes.
Subject: Adolescent
Adult
Aged
Brazil
Cervical Intraepithelial Neoplasia
Dna, Viral
Epidemiologic Methods
Female
Human Papillomavirus 16
Human Papillomavirus 18
Humans
Middle Aged
Papillomaviridae
Papillomavirus Infections
Phylogeny
Urban Population
Uterine Cervical Neoplasms
Young Adult
Citation: São Paulo Medical Journal = Revista Paulista De Medicina. v. 127, n. 3, p. 122-7, 2009.
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/19820871
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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