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Type: Artigo de periódico
Title: The Influence Of Lidocaine And Racemic Bupivacaine On Neuromuscular Blockade Produced By Rocuronium. A Study In Rat Phrenic Nerve-diaphragm Preparation.
Author: Carvalho, Vanessa Henriques
Braga, Angélica de Fátima de Assunção
Braga, Franklin Sarmento da Silva
Loyola, Yolanda Christina S
de Araújo, Daniele Ribeiro
Mantovani, Mario
Abstract: To evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium. Rats were distributed in 5 groups (n = 5) in agreement with the studied drugs: lidocaine, racemic bupivacaine, rocuronium, separately (Groups I, II, III); rocuronium in preparations exposed to local anesthetics (Groups IV, V). The concentrations used were: 20 microg/mL, 5 microg/mL and 4 microg/mL, for lidocaine, bupivacaine and rocuronium, respectively. It was evaluated: 1) amplitude of diaphragm muscle response to indirect stimulation, before and 60 minutes after separately addition of lidocaine, racemic bupivacaine and rocuronium and the association of local anesthetics - rocuronium; 2) membrane potentials (MP) and miniature end-plate potentials (MEPP). Lidocaine and bupivacaine separately didn't alter the amplitude of muscle response and MP. In preparations previously exposed to lidocaine and racemic bupivacaine, the rocuronium blockade was significantly larger (90.10 +/- 9.15% and 100%, respectively), in relation to the produced by rocuronium separately (73.12 +/- 9.89%). Lidocaine caused an increase in the frequency of MEPP, being followed by blockade; racemic bupivacaine produced decrease being followed by blockade. Local anesthetics potentiated the blockade caused by rocuronium. The alterations of MEPP identify presynaptic action.
Subject: Androstanols
Anesthetics, Local
Drug Evaluation, Preclinical
Electric Stimulation
Motor Endplate
Neuromuscular Blockade
Neuromuscular Junction
Neuromuscular Nondepolarizing Agents
Phrenic Nerve
Rats, Wistar
Statistics, Nonparametric
Citation: Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 24, n. 3, p. 211-5
Rights: aberto
Identifier DOI: 
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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