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Type: Artigo
Title: Identification of a bioactive compound isolated from brazilian propolis type 6
Author: Castro, Myrella Lessio
do Nascimento, Andréa Mendes
Ikegaki, Masaharu
Costa-Neto, Cláudio M.
Alencar, Severino M.
Rosalen, Pedro L.
Abstract: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
Subject: Própolis
Atividade biológica
Country: Reino Unido
Editor: Elsevier
Citation: Bioorganic & Medicinal Chemistry. v. 17, n. 14, p. 5332-5, 2009-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2009.04.066
Date Issue: 2009
Appears in Collections:FOP - Artigos e Outros Documentos

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