Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Translational Research Into Gut Microbiota: New Horizons In Obesity Treatment.
Author: Tsukumo, Daniela M
Carvalho, Bruno M
Carvalho-Filho, Marco A
Saad, Mário J A
Abstract: Obesity is a pandemic which has been rapidly developing for three decades. When a population is submitted to the same nutritional stress, some individuals are less susceptible to diet-induced weight gain and hyperglycemia. This observation suggests that other mechanisms are involved which are not directly related to the human genome. The human gut contains an immense number of microorganisms, collectively known as the microbiota. Evidence that gut microbiota composition can differ between obese and lean humans has led to the speculation that gut microbiota can participate in the pathophysiology of obesity. Different mechanisms have been proposed to explain the link between gut flora and obesity. The first mechanism consists in the role of the gut microbiota to increase energy extraction from indigestible dietary polysaccharides. The second, consists in the role of gut flora to modulate plasma lipopolysaccharide levels which triggers chronic low-grade inflammation leading to obesity and diabetes. A third mechanism proposes that gut microbiota may induce regulation of host genes that modulate how energy is expended and stored. However, further studies are needed to clarify a number of issues related to the relationship between the gut microbiota and obesity.
Subject: Animals
Bacterial Physiological Phenomena
Dietary Fats
Energy Intake
Energy Metabolism
Translational Medical Research
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. v. 53, n. 2, p. 139-44, 2009-Mar.
Rights: aberto
Identifier DOI: 
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_19466205.pdf218.95 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.