Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198314
Type: Artigo de periódico
Title: Landau-kleffner Syndrome: Long-term Follow-up.
Author: Duran, Marcos H C
Guimarães, Catarina A
Medeiros, Lívia L
Guerreiro, Marilisa M
Abstract: Landau-Kleffner syndrome (LKS) is a rare entity characterized by epilepsy and aphasia. It occurs in previously normal children, usually between three and seven years of age. The long-term outcome of LKS is not completely clear. The aim of this study is to verify the long-term follow-up of a group of patients with LKS, focusing on clinical and electroencephalographic (EEG) aspects, and quality of life. This was a transversal study. Between November 2006 and April 2007 seven patients with previous diagnosis of LKS were interviewed. They had had a follow-up of three to 16 years after their disease onset. They were all males between the ages of eight and 27 years old. All patients had normal MRI. Parents and/or patients were interviewed by one of the authors using a structured questionnaire. The Vineland Adaptive Behavior Scales, the Conner's Rating Scales-Revised, and Short-Form Health Survey (SF 36) were used. Each patient had a prolonged interictal EEG recording. All patients had normal MRI. The present investigation revealed that two patients still have seizures several years after epilepsy onset. One patient had total and three others had partial remission of language disturbance, while three patients still have aphasia and verbal auditory agnosia. With respect to quality of life, only one of our patients has a normal life at present. The remaining six patients with some sort of limitation consider the aphasia/agnosia to be the main difficulty in their lives. Five patients have normal EEGs. The long-term follow-up of patients with LKS shows that epilepsy and EEG abnormalities do not always disappear. Language disturbances tend to persist in most patients. The age of onset of language dysfunction does not seem to correlate with the prognosis for recovery of language function. Patients with LKS have an overall poor quality of life, mostly due to language difficulties.
Subject: Adolescent
Adult
Age Factors
Agnosia
Aphasia
Child
Electroencephalography
Epilepsy
Follow-up Studies
Humans
Landau-kleffner Syndrome
Language Disorders
Magnetic Resonance Imaging
Male
Prognosis
Quality Of Life
Questionnaires
Time Factors
Young Adult
Citation: Brain & Development. v. 31, n. 1, p. 58-63, 2009-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.braindev.2008.09.007
Address: http://www.ncbi.nlm.nih.gov/pubmed/18930363
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_18930363.pdf517.71 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.