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Type: Artigo de periódico
Title: Chicken Dapper Genes Are Versatile Markers For Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, And Neurogenic Placodes.
Author: Alvares, Lúcia Elvira
Winterbottom, Farrah Leigh
Jorge, Erika Cristina
Rodrigues Sobreira, Débora
Xavier-Neto, José
Schubert, Frank Richard
Dietrich, Susanne
Abstract: Dapper (Dpr) proteins are context-dependent regulators of Wnt and Tgfbeta signaling. However, although inroads into their molecular properties have been made, their expression and biological function are not understood. Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only. The genes are expressed in distinct patterns at gastrulation, neurulation, and organogenesis stages of development with key expression domains being the posterior primitive streak, anterior node and notochord, presomitic mesoderm (segmental plate), lateral and cardiac mesoderm, limb mesenchyme, and neurogenic placodes for Dpr1, and anterior primitive streak, node, epithelial somites, embryonic muscle stem cells, oral ectoderm and endoderm, neural crest cells, limb ectoderm, and lung buds for Dpr2. Expression overlaps in a few tissues; however, in several tissues, expression is complementary.
Subject: Animals
Chick Embryo
Embryo, Nonmammalian
Embryonic Stem Cells
Gene Expression Regulation, Developmental
Genetic Markers
Intracellular Signaling Peptides And Proteins
Neural Crest
Rights: fechado
Identifier DOI: 10.1002/dvdy.21950
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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