Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198237
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect Of Low Intensity Helium-neon (hene) Laser Irradiation On Experimental Paracoccidioidomycotic Wound Healing Dynamics.pt_BR
dc.contributor.authorFerreira, Maria Carolinapt_BR
dc.contributor.authorGameiro, Jacypt_BR
dc.contributor.authorNagib, Patrícia Resende Alopt_BR
dc.contributor.authorBrito, Vânia Nietopt_BR
dc.contributor.authorVasconcellos, Elza da Costa Cruzpt_BR
dc.contributor.authorVerinaud, Lianapt_BR
unicamp.authorMaria Carolina Ferreira, Department of Microbiology, Institute of Biology, State University at Campinas (UNICAMP), Campinas, SP, Brazil.pt_BR
unicamp.author.externalJacy Gameiro,pt
unicamp.author.externalPatrícia Resende Alo Nagib,pt
unicamp.author.externalVânia Nieto Brito,pt
unicamp.author.externalElza da Costa Cruz Vasconcellos,pt
unicamp.author.externalLiana Verinaud,pt
dc.subjectAnimalspt_BR
dc.subjectChemokine Cxcl10pt_BR
dc.subjectInterleukin-10pt_BR
dc.subjectInterleukin-1betapt_BR
dc.subjectLaser Therapy, Low-levelpt_BR
dc.subjectLasers, Gaspt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred Balb Cpt_BR
dc.subjectParacoccidioidomycosispt_BR
dc.subjectWound Healingpt_BR
dc.description.abstractThe effect of HeNe laser on the extracellular matrix deposition, chemokine expression and angiogenesis in experimental paracoccidioidomycotic lesions was investigated. At days 7, 8 and 9 postinfection the wound of each animal was treated with a 632.8 nm HeNe laser at a dose of 3 J cm(-2). At day 10 postinfection, the wounds were examined by using histologic and immunohistochemical methods. Results revealed that laser-treated lesions were lesser extensive than untreated ones, and composed mainly by macrophages and lymphocytes. High IL-1beta expression was shown in the untreated group whereas in laser-treated animals the expression was scarce. On the other hand, the expression of CXCL-10 was found to be reduced in untreated animals and quite intensive and well distributed in the laser-treated ones. Also, untreated lesions presented vascular endothelial growth factor (VEGF) in a small area near the center of the lesion and high immunoreactivity for hypoxia-inducible factor-1 (HIF-1), whereas laser-treated lesions expressed VEGF surrounding blood vessels and little immunoreactivity for HIF-1. Laser-treated lesions presented much more reticular fibers and collagen deposition when compared with the untreated lesion. Our results show that laser was efficient in minimizing the local effects observed in paracoccidioidomycosis and can be an efficient tool in the treatment of this infection, accelerating the healing process.en
dc.relation.ispartofPhotochemistry And Photobiologypt_BR
dc.relation.ispartofabbreviationPhotochem. Photobiol.pt_BR
dc.date.issuedpt_BR
dc.identifier.citationPhotochemistry And Photobiology. v. 85, n. 1, p. 227-33pt_BR
dc.language.isoengpt_BR
dc.description.volume85pt_BR
dc.description.firstpage227-33pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0031-8655pt_BR
dc.identifier.doi10.1111/j.1751-1097.2008.00423.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18764901pt_BR
dc.date.available2015-11-27T13:15:01Z-
dc.date.accessioned2015-11-27T13:15:01Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:15:01Z (GMT). No. of bitstreams: 1 pmed_18764901.pdf: 1160732 bytes, checksum: a30aea7978c262f20c63d49f9d78dceb (MD5) Previous issue date: nullen
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198237-
dc.identifier.idPubmed18764901pt_BR
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