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Type: Artigo de periódico
Title: T Allele Of -344 C/t Polymorphism In Aldosterone Synthase Gene Is Not Associated With Resistant Hypertension.
Author: Lacchini, Riccardo
Sabha, Maricene
Coeli, Fernanda B
Favero, Fabrício F
Yugar-Toledo, Juan
Izidoro-Toledo, Tatiane C
Sandrim, Valéria C
Tanus-Santos, José E
de Mello, Maricilda P
Moreno, Heitor
Abstract: Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.
Subject: Adult
Blood Pressure
Carotid Arteries
Cytochrome P-450 Cyp11b2
Drug Resistance
Gene Frequency
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Rights: aberto
Identifier DOI: 10.1038/hr.2008.36
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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