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Type: Artigo de periódico
Title: Focal Adhesion Kinase Signaling In Cardiac Hypertrophy And Failure.
Author: Franchini, K G
Clemente, C F M Z
Marin, T M
Abstract: Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Subject: Animals
Cell Proliferation
Focal Adhesion Protein-tyrosine Kinases
Heart Failure
Myocytes, Cardiac
Signal Transduction
Citation: Brazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 42, n. 1, p. 44-52, 2009-Jan.
Rights: aberto
Identifier DOI: 
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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