Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198201
Type: Artigo de periódico
Title: Focal Adhesion Kinase Signaling In Cardiac Hypertrophy And Failure.
Author: Franchini, K G
Clemente, C F M Z
Marin, T M
Abstract: Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Subject: Animals
Cardiomegaly
Cell Proliferation
Fibroblasts
Focal Adhesion Protein-tyrosine Kinases
Heart Failure
Humans
Myocytes, Cardiac
Signal Transduction
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/19219296
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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