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Type: | Artigo de periódico |
Title: | Anti-inflammatory Effect Of Lycopene On Carrageenan-induced Paw Oedema And Hepatic Ischaemia-reperfusion In The Rat. |
Author: | Bignotto, Letícia Rocha, João Sepodes, Bruno Eduardo-Figueira, Maria Pinto, Rui Chaud, Marco de Carvalho, João Moreno, Heitor Mota-Filipe, Helder |
Abstract: | The regular intake of tomatoes or its products has been associated with a reduced risk of chronic diseases and these effects have been mainly attributed to lycopene. Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema model in rats was performed. Lycopene was administered as an acute (1, 10, 25 or 50 mg/kg, intraperitoneally, 15 min before carrageenan injection) and chronic treatment (25 or 50 mg/kg per d, 14 d). Inflammation was assessed by the measurement of paw volume increase after 6 h. Lycopene significantly inhibited paw oedema formation at two doses (25 and 50 mg/kg) in both acute and repeated administration. The effect of lycopene on liver inflammation was evaluated in a liver ischaemia-reperfusion (I/R) model. Rats were subjected to 45 min of ischaemia of three-quarters of the liver followed by 2 h of reperfusion. In this model, lycopene was administered daily at two doses (25 and 50 mg/kg) during the 14 d that preceded the experiments. Repeated administration of lycopene reduced liver injury induced by I/R, as demonstrated by the reduction of the increase in liver injury markers (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and gamma-glutamyl transferase) and attenuation of liver tissue lipoperoxidation was evidenced by a decrease in malondialdehyde production. The present results show that lycopene exhibited local anti-inflammatory activity and also attenuated liver injury induced by I/R. We speculate that lycopene administration might be useful in the pharmacological modulation of inflammatory events. |
Subject: | Acute Disease Animals Antioxidants Biological Markers Carotenoids Carrageenan Chronic Disease Edema Hindlimb Lipid Peroxidation Liver Liver Diseases Male Models, Animal Phytotherapy Rats Rats, Wistar Reperfusion Injury |
Citation: | The British Journal Of Nutrition. v. 102, n. 1, p. 126-33, 2009-Jul. |
Rights: | fechado |
Identifier DOI: | 10.1017/S0007114508137886 |
Address: | http://www.ncbi.nlm.nih.gov/pubmed/19203414 |
Date Issue: | 2009 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
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pmed_19203414.pdf | 231.97 kB | Adobe PDF | View/Open |
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