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Type: Artigo de periódico
Title: Anti-inflammatory Effect Of Lycopene On Carrageenan-induced Paw Oedema And Hepatic Ischaemia-reperfusion In The Rat.
Author: Bignotto, Letícia
Rocha, João
Sepodes, Bruno
Eduardo-Figueira, Maria
Pinto, Rui
Chaud, Marco
de Carvalho, João
Moreno, Heitor
Mota-Filipe, Helder
Abstract: The regular intake of tomatoes or its products has been associated with a reduced risk of chronic diseases and these effects have been mainly attributed to lycopene. Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema model in rats was performed. Lycopene was administered as an acute (1, 10, 25 or 50 mg/kg, intraperitoneally, 15 min before carrageenan injection) and chronic treatment (25 or 50 mg/kg per d, 14 d). Inflammation was assessed by the measurement of paw volume increase after 6 h. Lycopene significantly inhibited paw oedema formation at two doses (25 and 50 mg/kg) in both acute and repeated administration. The effect of lycopene on liver inflammation was evaluated in a liver ischaemia-reperfusion (I/R) model. Rats were subjected to 45 min of ischaemia of three-quarters of the liver followed by 2 h of reperfusion. In this model, lycopene was administered daily at two doses (25 and 50 mg/kg) during the 14 d that preceded the experiments. Repeated administration of lycopene reduced liver injury induced by I/R, as demonstrated by the reduction of the increase in liver injury markers (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and gamma-glutamyl transferase) and attenuation of liver tissue lipoperoxidation was evidenced by a decrease in malondialdehyde production. The present results show that lycopene exhibited local anti-inflammatory activity and also attenuated liver injury induced by I/R. We speculate that lycopene administration might be useful in the pharmacological modulation of inflammatory events.
Subject: Acute Disease
Biological Markers
Chronic Disease
Lipid Peroxidation
Liver Diseases
Models, Animal
Rats, Wistar
Reperfusion Injury
Citation: The British Journal Of Nutrition. v. 102, n. 1, p. 126-33, 2009-Jul.
Rights: fechado
Identifier DOI: 10.1017/S0007114508137886
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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