Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198162
Type: Artigo de periódico
Title: S-nitroso-n-acetylcysteine (snac) Prevents Myocardial Alterations In Hypercholesterolemic Ldl Receptor Knockout Mice By Antiinflammatory Action.
Author: Garcia, José Antonio D
dos Santos, Leandro
Moura, André L
Ricardo, Kelly Fabiane S
Wanschel, Amarylis Claudine B A
Shishido, Silvia M
Spadari-Bratfisch, Regina C
de Souza, Heraldo P
Krieger, Marta H
Abstract: We investigated the ability of S-nitroso-N-acetylcyseine (SNAC) to prevent structural and functional myocardial alterations in hypercholesterolemic mice. C57BL6 wild-type (WT) and LDL-R-/- male mice (S) were fed a standard diet for 15 days. LDL-R-/- mice (S) showed an 11% increase in blood pressure, 62% decrease in left atrial contractility, and lower CD40L and eNOS expression relative to WT. LDL-R-/- mice fed an atherogenic diet for 15 days (Chol) showed significant increased left ventricular mass compared to S, which was characterized by: (1) 1.25-fold increase in the LV weight/body weight ratio and cardiomyocyte diameter; (2) enhanced expression of the NOS isoforms, CD40L, and collagen amount; and (3) no alteration in the atrial contractile performance. Administration of SNAC to Chol mice (Chol + SNAC) (0.51 micromol/kg/day for 15 day, IP) prevented increased left ventricular mass, collagen deposit, NOS isoforms, and CD40L overexpression, but it had no effect on the increased blood pressure or atrial basal hypocontractility. Deletion of the LDL receptor gene in mice resulted in hypertension and a marked left atrial contractile deficit, which may be related to eNOS underexpression. Our data show that SNAC treatment has an antiinflammatory action that might contribute to prevention of structural and functional myocardial alterations in atherosclerotic mice independently of changes in blood pressure.
Subject: Acetylcysteine
Animals
Anti-inflammatory Agents
Blood Pressure
Cd40 Ligand
Gene Expression Regulation, Enzymologic
Hypercholesterolemia
Hypertension
Hypertrophy, Left Ventricular
Inflammation
Male
Mice
Mice, Inbred C57bl
Mice, Knockout
Myocardial Contraction
Nitric Oxide Synthase Type Iii
Receptors, Ldl
Rights: fechado
Identifier DOI: 10.1097/FJC.0b013e31815c39d4
Address: http://www.ncbi.nlm.nih.gov/pubmed/18209572
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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