Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198157
Type: Artigo de periódico
Title: Prevalence Of Transfusion-transmitted Chagas Disease Among Multitransfused Patients In Brazil.
Author: De Paula, Erich V
Goncales, Neiva S L
Xueref, Serge
Addas-Carvalho, Marcelo
Gilli, Simone C O
Angerami, Rodrigo N
Goncales, Fernando L
Abstract: Blood transfusion has always been an important route for Chagas Disease (CD) transmission. The high prevalence of CD in Latin America and its lifelong asymptomatic clinical picture pose a threat for the safety of the blood supply. The outcome of measures designed to improve transfusion safety can be assessed by evaluating the prevalence of CD among multitransfused patients In order to assess the impact of CD control measures on the safety of the blood supply, an observational cross-sectional study was designed to determine the prevalence of CD in 351 highly transfused patients, in which vectorial transmission was excluded. This study compared patients that received transfusion products before (n = 230) and after (n = 121) 1997, when measures to control transfusion-transmitted CD were fully implemented in Brazil. The study group consisted of 351 patients exposed to high numbers of blood products during their lifetime (median number of units transfused = 51, range 10-2086). A higher prevalence of transfusion-transmitted CD (1.30%) was observed among multitransfused patients that received their first transfusion before 1997, compared with no cases of transfusion-transmitted CD among multitransfused patients transfused after that year. The magnitude of the exposure to blood products was similar among both groups (mean number of units transfused per year of exposure = 25.00 +/- 26.46 and 23.99 +/- 30.58 respectively; P = 0.75, Mann-Whitney test). Multiple initiatives aimed to control vector and parental transmission of CD can significantly decrease transfusion-transmitted CD in Brazil. Our data suggest that mandatory donor screening for CD represents the most important measure to interrupt transmission of CD by blood transfusions.
Subject: Adolescent
Adult
Animals
Blood Transfusion
Brazil
Chagas Disease
Cross-sectional Studies
Female
Humans
Male
Mandatory Testing
Middle Aged
Seroepidemiologic Studies
Rights: aberto
Identifier DOI: 10.1186/1471-2334-8-5
Address: http://www.ncbi.nlm.nih.gov/pubmed/18199334
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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