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Type: Artigo de periódico
Title: Variant Isolates Of Human Metapneumovirus Subgroup B Genotype 1 In Campinas, Brazil.
Author: da Silva, Luciana Helena Antoniassi
Spilki, Fernando Rosado
Riccetto, Adriana Gut Lopes
de Almeida, Renata Servan
Baracat, Emílio Carlos Elias
Arns, Clarice Weis
Abstract: Human metapneumovirus (HMPV) is a paramyxovirus associated with respiratory illness. The genotypes of HMPV isolates in Brazil have not been well characterized. To investigate the presence of HMPV in clinical samples collected from pediatric patients of two university hospitals in the region of Campinas (São Paulo, Brazil) and to genotype them by partial sequencing of the HMPV F gene. Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI). We identified HMPV in 8 of 142 (5.6%) clinical samples. We determined through phylogenetic analysis that HMPV isolates in Campinas during the study were clustered within subgroup B genotype 1. Two of the isolates analyzed showed significant differences from previously isolated B1 viruses, when compared to HMPV isolated in South Africa and Canada, and clustered in a separate branch within this genotype. In 2004 in our geographic region all HMPV isolates from pediatric patients were in the B1 HMPV genetic group, with two variant isolates.
Subject: Base Sequence
Cluster Analysis
Hospitals, University
Molecular Sequence Data
Paramyxoviridae Infections
Polymorphism, Genetic
Rna, Viral
Sequence Alignment
Sequence Analysis, Dna
Rights: fechado
Identifier DOI: 10.1016/j.jcv.2007.11.010
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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