Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198063
Type: Artigo de periódico
Title: Comparative Study Of Patients With Chronic Hepatitis C Virus Infection Due To Genotypes 1 And 3 Referred For Treatment In Southeast Brazil.
Author: Vigani, Aline G
Pavan, Maria H
Tozzo, Raquel
Gonçales, Eduardo S L
Feltrin, Adriana
Fais, Viviane C
Lazarini, Maria S K
Gonçales, Neiva S L
Gonçales, Fernando L
Abstract: The progression of liver disease in patients with chronic hepatitis C virus (HCV) infection is influenced by host and viral factors. Distinct clinical outcomes in patients infected with different HCV genotypes have been described in the literature. However, the association between specific HCV genotype and clinical outcome remains unclear. We set out to study the natural history of HCV genotype 1 and 3 infections in Campinas, São Paulo state, Brazil, focusing on epidemiological, clinical, biochemical, and histological characteristics. Patients with HCV infection referred for treatment between January 2003 and December 2006 were included in this study. We collected epidemiological, clinical, and laboratorial data using standard forms. A total of 283 patients were included; genotype 1 was identified in 163 (57.6%) patients, genotype 3 in 112 (39.6%), genotype 2 in 7 (2.5%), and genotype 4 in 1 (0.35%). Patients with genotype 2 and 4 were excluded from analysis. Multivariate analysis showed that intravenous energetic drug, positive cryoglobulin, and cirrhosis were independently and significantly associated with HCV genotype 3 (p < 0.05). Genotype 3 currently seems to be associated with intravenous energetic drug, high frequency of cryoglobulinemia, and advanced liver disease in our region. Understanding the distribution of the different HCV genotypes can elucidate transmission of HCV and support optimal prevention strategies.
Subject: Adult
Aged
Brazil
Female
Genotype
Hepacivirus
Hepatitis C, Chronic
Humans
Male
Middle Aged
Treatment Outcome
Young Adult
Rights: aberto
Identifier DOI: 10.1186/1471-2334-8-164
Address: http://www.ncbi.nlm.nih.gov/pubmed/19055835
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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