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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt
dc.typeArtigo de periódicopt
dc.titleDiet-induced Inflammation Of The Hypothalamus In Obesity.pt
dc.contributor.authorVelloso, Lício Apt
dc.contributor.authorAraújo, Eliana Ppt
dc.contributor.authorde Souza, Cláudio Tpt
unicamp.authorLício A Velloso, Department of Internal Medicine, State University of Campinas, Campinas, Brazil. lavelloso@fcm.unicamp.brpt
unicamp.author.externalEliana P Araújo,pt
unicamp.author.externalCláudio T de Souza,pt
dc.subjectAnimalspt
dc.subjectBody Weightpt
dc.subjectCytokinespt
dc.subjectDietary Fatspt
dc.subjectEncephalitispt
dc.subjectHumanspt
dc.subjectHypothalamuspt
dc.subjectInsulinpt
dc.subjectInsulin Resistancept
dc.subjectLeptinpt
dc.subjectObesitypt
dc.subjectSignal Transductionpt
dc.description.abstractDysfunction of specific hypothalamic neurons is regarded as an important mechanism predisposing to the development of obesity. Recent studies have revealed that the consumption of fat-rich foods can activate an inflammatory response in the hypothalamus, which disturbs the anorexigenic and thermogenic signals generated by the hormones leptin and insulin, leading in turn to anomalous body mass control. Depending on diet composition, cytokines are expressed in the hypothalamus, contributing to the activation of intracellular inflammatory signal transduction. At least 4 distinct signaling pathways have been identified and the molecular mechanisms leading to the impairment of the leptin and insulin actions have been determined. Here, we present the mechanisms involved in diet-induced resistance to leptin and insulin action in the hypothalamus and discuss some of the potential applications of this knowledge in the therapeutics of obesity.en
dc.relation.ispartofNeuroimmunomodulationen
dc.relation.ispartofabbreviationNeuroimmunomodulationpt
dc.date.issued2008pt
dc.identifier.citationNeuroimmunomodulation. v. 15, n. 3, p. 189-93, 2008.pt
dc.language.isoengpt
dc.description.volume15pt
dc.description.initialpage189-93pt
dc.rightsfechadopt
dc.rights.holder2008 S. Karger AG, Basel.pt
dc.sourcePubMedpt
dc.identifier.issn1423-0216pt
dc.identifier.doi10.1159/000153423pt
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18781083en
dc.date.available2015-11-27T13:13:11Z-
dc.date.accessioned2015-11-27T13:13:11Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:13:11Z (GMT). No. of bitstreams: 1 pmed_18781083.pdf: 204698 bytes, checksum: 52a072fdecdcf9ce9507827b3c7143fb (MD5) Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197970-
dc.identifier.idPubmed18781083pt
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