Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197970
Type: Artigo de periódico
Title: Diet-induced Inflammation Of The Hypothalamus In Obesity.
Author: Velloso, Lício A
Araújo, Eliana P
de Souza, Cláudio T
Abstract: Dysfunction of specific hypothalamic neurons is regarded as an important mechanism predisposing to the development of obesity. Recent studies have revealed that the consumption of fat-rich foods can activate an inflammatory response in the hypothalamus, which disturbs the anorexigenic and thermogenic signals generated by the hormones leptin and insulin, leading in turn to anomalous body mass control. Depending on diet composition, cytokines are expressed in the hypothalamus, contributing to the activation of intracellular inflammatory signal transduction. At least 4 distinct signaling pathways have been identified and the molecular mechanisms leading to the impairment of the leptin and insulin actions have been determined. Here, we present the mechanisms involved in diet-induced resistance to leptin and insulin action in the hypothalamus and discuss some of the potential applications of this knowledge in the therapeutics of obesity.
Subject: Animals
Body Weight
Cytokines
Dietary Fats
Encephalitis
Humans
Hypothalamus
Insulin
Insulin Resistance
Leptin
Obesity
Signal Transduction
Rights: fechado
Identifier DOI: 10.1159/000153423
Address: http://www.ncbi.nlm.nih.gov/pubmed/18781083
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_18781083.pdf199.9 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.