Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197949
Type: Artigo de periódico
Title: Morphometric Evaluation Of The Repair Of Critical-size Defects Using Demineralized Bovine Bone And Autogenous Bone Grafts In Rat Calvaria.
Author: de Oliveira, Rodrigo Cardoso
de Oliveira, Fabio Henrique Gelonese
Cestari, Tânia Mary
Taga, Rumio
Granjeiro, José Mauro
Abstract: To evaluate the repair of critical-size bone defects in rats treated with demineralized bovine bone (DBB) compared with autogenous bone (AB). A bone defect of 8 mm in diameter was created in the calvaria of 50 Rattus norvegicus, treated either with DBB or AB. Sub-groups of five rats of each group were killed at 7, 14, 21, 30 and 90 days post-operatively, and the skulls were removed and processed histologically. Histological sections were stained with hematoxylin and eosin. Histological analysis showed complete closure of the defects with new bone at 90 days in group AB, and substitution of the biomaterial by fibrotic connective tissue in the DBB group at 21 days. Morphometric analysis showed that DBB was rapidly absorbed at 14 days, with its volume density decreasing from 47%+/-0.8% at 7 days to 1.2%+/-0.41% at 14 days. Subsequently, volume densities of the connective tissue and neoformed bone increased from 51.1%+/-11.17% to 86.8%+/-7.92% and from 1.9%+/-1.13% to 12%+/-8.02%, respectively, for the same time interval. The volume density of AB particles did not change throughout the experimental periods, but the amount of new bone increased markedly between 7 and 90 days, from 4.5%+/-1.57% to 53.5%+/-6.42% (P<0.05). DBB did not provide complete repair of the defects, with significantly less new bone formation than in the AB group.
Subject: Absorbable Implants
Animals
Biocompatible Materials
Bone Matrix
Bone Regeneration
Bone Substitutes
Bone Transplantation
Cattle
Craniotomy
Male
Osteogenesis
Rats
Rats, Wistar
Skull
Time Factors
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/18720554
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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