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Type: Artigo de periódico
Title: Estimation Of Absolute Renal Uptake With Technetium-99m Dimercaptosuccinic Acid: Direct Comparison With The Radioactivity Of Nephrectomy Specimens.
Author: Lopes de Lima, Mariana da Cunha
Ramos, Celso Darío
Brunetto, Sérgio Quirino
Lopes de Lima, Marcelo
Ferreira, Ubirajara
Sá Camargo Etchebehere, Elba Cristina
Santos, Allan de Oliveira
Rodrigues Netto Júnior, Nelson
Camargo, Edwaldo Eduardo
Abstract: Studies using radionuclides are the most appropriate method for estimating renal function. Dimercaptosuccinic acid chelate labeled with technetium-99m (99mTc-DMSA) is the radiopharmaceutical of choice for high-resolution imaging of the renal cortex and estimation of the functional renal mass. The aim of this study was to evaluate a simplified method for determining the absolute renal uptake (ARU) of 99mTc-DMSA prior to nephrectomy, using the radioactivity counts of nephrectomy specimens as the gold standard. Prospective study at the Division of Nuclear Medicine, Department of Radiology, Universidade Estadual de Campinas. Seventeen patients (12 females; range 22-82 years old; mean age 50.8 years old) underwent nephrectomy for various reasons. Renal scintigraphy was performed three to four hours after intravenous administration of a mean dose of 188.7 MBq (5.1 mCi) of 99mTc-DMSA, which was done six to 24 hours before surgery. The in vivo renal uptake of 99mTc-DMSA was determined using the radioactivity of the syringe before the injection (measured using a dose calibrator) and the images of the syringe and kidneys, obtained from a scintillation camera. After surgery, the reference value for renal uptake of 99mTc-DMSA was determined by measuring the radioactivity of the nephrectomy specimen using the same dose calibrator. The ARU measurements were very similar to those obtained using the reference method, as determined by linear regression (r-squared = 0.96). ARU estimation using the proposed method before nephrectomy seems to be accurate and feasible for routine use.
Subject: Adult
Aged, 80 And Over
Feasibility Studies
Kidney Diseases
Kidney Function Tests
Linear Models
Middle Aged
Prospective Studies
Technetium Tc 99m Dimercaptosuccinic Acid
Young Adult
Citation: São Paulo Medical Journal = Revista Paulista De Medicina. v. 126, n. 3, p. 150-5, 2008-May.
Rights: aberto
Identifier DOI: 
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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