Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197896
Type: Artigo de periódico
Title: Experimental Carcinogenesis On The Oropharyngeal Mucosa Of Rats With Hydrochloric Acid, Sodium Nitrate And Pepsin.
Author: Del Negro, André
Araújo, Marina Raquel
Tincani, Alfio José
Meirelles, Luciana
Martins, Antônio Santos
Andreollo, Nelson Adami
Abstract: To investigate the carcinogenic action of hydrochloric acid, pepsin and sodium nitrate on the oropharyngeal mucosa of rats, simulating the reflux of gastric contents. Eighty-two Wistar rats were divided in seven groups and submitted to 2 or 3 weekly applications of hydrochloric acid, pepsin and sodium nitrate on the pharyngeal mucosa during six months. Study groups comprised 12 animals each. Rats in groups I and II were submitted to 2 (GI) or 3 (GII) weekly applications of 0.1N hydrochloric acid. Groups III and IV were submitted to 2 (GIII) or 3 (GIV) weekly applications of 0.1N hydrochloric acid solution with pepsin. Groups V and VI were submitted to 2 (GV) or 3 (GVI) weekly applications of 0.1N hydrochloric acid and treated with daily nitrate diluted in water. Group VII consisted of 10 animals submitted to 2 weekly applications of filtered water. No dysplasia, intra-epithelial neoplasia or invasive carcinomas were detected. Inflammatory changes were observed in varying degrees and mast cells were more common in Groups V and VI (p=0.006). The data of the current study could not corroborate the hypothesis that gastroesophageal and pharyngolaryngeal refluxes are carcinogenic factors to the laryngopharyngeal mucosa, and more studies are necessary in the future.
Subject: Animals
Carcinogenicity Tests
Carcinogens
Carcinoma, Squamous Cell
Drug Evaluation, Preclinical
Gastrointestinal Agents
Hydrochloric Acid
Male
Mouth Mucosa
Nitrates
Oropharyngeal Neoplasms
Pepsin A
Random Allocation
Rats
Rats, Wistar
Citation: Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 23, n. 4, p. 337-42
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/18641803
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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