Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197894
Type: Artigo de periódico
Title: Diagnosis And Follow-up Of Keratoacanthoma-like Lesions: Clinical-histologic Study Of 43 Cases.
Author: Magalhães, Renata Ferreira
Cruvinel, Gabriela Torres
Cintra, Geórgia Fontes
Cintra, Maria Letícia
Ismael, Ana Paula Palu Baltieri
de Moraes, Aparecida Machado
Abstract: Keratoacanthoma (KA) is easily confused with squamous cell carcinoma (SCC) on a clinical or a histopathologic basis. However, KA undergoes spontaneous regression, whereas SCC does not. Our objective was to study the histopathologic features associated with clinical regression in KA-like lesions to support the therapeutic option. Forty-three biopsies of KA-like lesions were taken at patient admission. One month later, surgical excision was performed in 18 growing lesions. Regressing lesions were left untreated. Classic histopathologic features and diagnosis were blindly recorded in both biopsies and surgical specimens. On a clinical and a histologic basis, 32 lesions were assessed as KA and 11 as SCC. Features that indicated malignancy were observed in both groups, but the probability of SCC was 31 times higher in tumors with five or more of such features. Several of the histologically atypical lesions were found to regress. SCCs and KAs have more pathologic similarities than differences, especially in the proliferative phase. The combination of the most useful features did not allow the nosologic diagnosis in difficult cases but helped. Differential diagnosis was easier to determine after the 1-month follow up. Complete surgical excision should be indicated in nonregressing and growing lesions.
Subject: Adult
Aged
Aged, 80 And Over
Biopsy
Carcinoma, Squamous Cell
Chi-square Distribution
Diagnosis, Differential
Female
Humans
Keratoacanthoma
Logistic Models
Male
Middle Aged
Skin Diseases
Skin Neoplasms
Statistics, Nonparametric
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/18627696
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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