Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197852
Type: Artigo de periódico
Title: Peroxiredoxin I Is Differentially Expressed In Multiple Myelomas And In Plasmablastic Lymphomas.
Author: Demasi, A P D
Magalhães, M H C
Furuse, C
Araújo, N S
Junqueira, J L C
Araújo, V C
Abstract: Plasmablastic lymphoma (PBL) and multiple myeloma (MM) are B cell-derived malignancies that share many morphologic and immunophenotypic traits, making the differential diagnosis particularly complicated. We have recently demonstrated that peroxiredoxin I (PrdxI) is expressed in plasma cells but not in B lymphocytes, suggesting that its expression is development-associated. To analyze PrdxI expression in PBL and in MM in order to study its utilization as an additional diagnostic molecular tool. Eight cases of PBL and nine of MM were studied by immunohistochemistry. We have demonstrated that PrdxI expression is closely connected with the immunoglobulin production capacity of the cells, which means high in MM, but absent in PBL cases, except one, wherein few cells were stained. We hypothesize PrdxI as a component of the unfolded protein response (UPR), an adaptive pathway essential for plasma cell differentiation. As we have not detected immunoglobulin in our PBL cases, we suggest that UPR was not activated in the cells, accounting for the impediment of the developmental process, and for the inhibition of PrdxI expression observed. PrdxI could be considered an additional plasma cell functional marker and could also be speculated as a therapeutic target in the treatment of MM.
Subject: Adult
Aged
Antibodies, Monoclonal
Antigens, Cd20
B-lymphocytes
Child
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin Kappa-chains
Immunoglobulin Lambda-chains
Immunohistochemistry
Lymphoma, Large B-cell, Diffuse
Male
Middle Aged
Multiple Myeloma
Peroxiredoxins
Plasma Cells
Plasmacytoma
Tumor Markers, Biological
Rights: fechado
Identifier DOI: 10.1111/j.1601-0825.2008.01455.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/18565146
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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