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Type: Artigo de periódico
Title: Reduction Of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin And Leptin Resistance In Diet-induced Obese Rats.
Author: Picardi, Paty Karoll
Calegari, Vivian Cristine
Prada, Patricia Oliveira
Prada, Patrícia de Oliveira
Moraes, Juliana Contin
Araújo, Eliana
Marcondes, Maria Cristina Cintra Gomes
Ueno, Miriam
Carvalheira, José Barreto Campello
Velloso, Licio Augusto
Saad, Mario José Abdalla
Abstract: Protein tyrosine phosphatase (PTP1B) has been implicated in the negative regulation of insulin and leptin signaling. PTP1B knockout mice are hypersensitive to insulin and leptin and resistant to obesity when fed a high-fat diet. We investigated the role of hypothalamic PTP1B in the regulation of food intake, insulin and leptin actions and signaling in rats through selective decreases in PTP1B expression in discrete hypothalamic nuclei. We generated a selective, transient reduction in PTP1B by infusion of an antisense oligonucleotide designed to blunt the expression of PTP1B in rat hypothalamic areas surrounding the third ventricle in control and obese rats. The selective decrease in hypothalamic PTP1B resulted in decreased food intake, reduced body weight, reduced adiposity after high-fat feeding, improved leptin and insulin action and signaling in hypothalamus, and may also have a role in the improvement in glucose metabolism in diabetes-induced obese rats.
Subject: Adiposity
Body Weight
Diet, Atherogenic
Drug Resistance
Injections, Intraventricular
Oligonucleotides, Antisense
Protein Tyrosine Phosphatases
Rats, Wistar
Signal Transduction
Citation: Endocrinology. v. 149, n. 8, p. 3870-80, 2008-Aug.
Rights: fechado
Identifier DOI: 10.1210/en.2007-1506
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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