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Type: Artigo de periódico
Title: Dexamethasone Treatment In Vivo Counteracts The Functional Pancreatic Islet Alterations Caused By Malnourishment In Rats.
Author: Giozzet, Vanessa A G
Rafacho, Alex
Boschero, Antonio C
Carneiro, Everardo M
Bosqueiro, José R
Abstract: The effects of dexamethasone (Dex) on the metabolic parameters, peripheral insulin, and glucose sensitivity in vivo as well as on islet function ex vivo of rats submitted to low-protein diet were analyzed. Dexamethasone (1.0 mg/kg body weight) was administered intraperitoneally daily to adult Wistar rats fed on a normal-protein diet or low-protein diet (LPD) for 5 days, whereas control rats fed on a normal-protein diet or low-protein diet (LP) received saline alone. At the end of the experimental period, LP rats showed a significant reduction in serum insulin, total serum protein, and serum albumin levels compared with rats fed on a normal-protein diet (P<.05). All these parameters tended to be normalized in LPD rats (P<.05); furthermore, these rats exhibited increased serum glucose and nonesterified fatty acid levels compared with LP rats (P<.05). Rats submitted to the low-protein diet demonstrated normal peripheral glucose sensitivity and improved peripheral insulin sensitivity, which was reversed by Dex treatment. A reduced area of islets from LP rats was partially recovered in LPD rats (P<.05). At 16.7 mmol/L glucose, insulin secretion from LPD islets was also partially recovered and was significantly higher than that from LP islets (P<.05). In conclusion, induction of insulin resistance by Dex treatment reverses most of the metabolic alterations in rats submitted to a low-protein diet. In addition, several islet functions were also improved by Dex, confirming the plasticity of pancreatic islets in adverse conditions.
Subject: Animals
Blood Glucose
Fatty Acids, Nonesterified
Insulin Resistance
Islets Of Langerhans
Protein Deficiency
Rats, Wistar
Rights: fechado
Identifier DOI: 10.1016/j.metabol.2007.12.004
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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