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Type: Artigo de periódico
Title: Disodium Cromoglycate Protects Dystrophin-deficient Muscle Fibers From Leakiness.
Author: Marques, Maria Julia
Ventura Machado, Rafael
Minatel, Elaine
Santo Neto, Humberto
Abstract: In dystrophin-deficient fibers of mdx mice and in Duchenne dystrophy, the lack of dystrophin leads to sarcolemma breakdown and muscle degeneration. We verified that cromolyn, a mast-cell stabilizer agent, stabilized dystrophic muscle fibers using Evans blue dye as a marker of sarcolemma leakiness. Mdx mice (n=8; 14 days of age) received daily intraperitoneal injections of cromolyn (50 mg/kg body weight) for 15 days. Untreated mdx mice (n=8) were injected with saline. Cryostat cross-sections of the sternomastoid, tibialis anterior, and diaphragm muscles were stained with hematoxylin and eosin. Cromolyn dramatically reduced Evans blue dye-positive fibers in all muscles (P<0.05; Student's t-test) and led to a significant increase in the percentage of fibers with peripheral nuclei. This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin.
Subject: Animals
Anti-asthmatic Agents
Cell Membrane Permeability
Cromolyn Sodium
Disease Models, Animal
Ion Channels
Mast Cells
Mice, Inbred Mdx
Muscle Fibers, Skeletal
Muscle, Skeletal
Muscular Dystrophy, Animal
Muscular Dystrophy, Duchenne
Treatment Outcome
Water-electrolyte Balance
Citation: Muscle & Nerve. v. 37, n. 1, p. 61-7, 2008-Jan.
Rights: fechado
Identifier DOI: 10.1002/mus.20892
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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