Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197723
Type: Artigo de periódico
Title: Antithrombogenic Polynitrosated Polyester/poly(methyl Methacrylate) Blend For The Coating Of Blood-contacting Surfaces.
Author: Seabra, Amedea B
da Silva, Regiane
de Souza, Gabriela F P
de Oliveira, Marcelo G
Abstract: A nitric oxide (NO) donor polyester containing multiple S-nitrosothiol (S-NO) groups covalently attached to the polymer backbone was synthesized through the esterification of poly(ethylene glycol) with mercaptosuccinic acid, followed by the nitrosation of the -SH moieties. The polynitrosated polyester (PNPE) obtained was blended with poly(methyl methacrylate) (PMMA), yielding solid films capable of releasing NO. Scanning electron microscopy analysis showed that acrylic plates and stainless steel intracoronary stents can be coated with continuous and adherent PNPE/PMMA films. After an initial NO burst, these films release NO spontaneously in dry condition or immersed in aqueous solution at constant rates of 1.8 and 180 nmol/g/h, respectively, for more than 24 h at physiological temperature. PNPE/PMMA coated surfaces were shown to inhibit platelet adhesion when in contact with whole blood. These results show that PNPE/PMMA blend can be used for the coating of blood-contacting surfaces, with potential to inhibit thrombosis and restenosis after stenting.
Subject: Acrylates
Biocompatible Materials
Blood Platelets
Coronary Restenosis
Delayed-action Preparations
Drug-eluting Stents
Fibrinolytic Agents
Humans
Kinetics
Materials Testing
Nitric Oxide
Nitric Oxide Donors
Platelet Adhesiveness
Polyesters
Polymethyl Methacrylate
Prosthesis Design
S-nitrosothiols
Stainless Steel
Surface Properties
Thrombosis
Rights: fechado
Identifier DOI: 10.1111/j.1525-1594.2008.00540.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/18370938
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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