Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197708
Type: Artigo de periódico
Title: Antiproliferative Properties Of Polyketides Isolated From Virola Sebifera Leaves.
Author: Denny, Carina
Zacharias, Marcela Engelbrecht
Ruiz, Ana Lúcia Tasca Gois
do Carmo E do Amaral, Maria
Bittrich, Volker
Kohn, Luciana Konecny
de Oliveira Sousa, Ilza Maria
Rodrigues, Rodney Alexandre Ferreira
de Carvalho, João Ernesto
Foglio, Mary Ann
Abstract: An activity-guided fractionation of Virola sebifera Aubl. methylene chloride-soluble fraction provided novel 3,5-dihydro-2-(1'-oxo-3'-hexadecenyl)-2-cyclohexen-1-one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1-4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal) and NCI-ADR (breast expressing phenotype multiple drugs resistance) in vitro. The new polyketide (3) showed selectivity against human OVCAR03 and NCI-ADR cell lines, ranging from 2 to 4 microg/mL.
Subject: Cell Line, Tumor
Cell Proliferation
Dose-response Relationship, Drug
Ht29 Cells
Humans
Macrolides
Magnetic Resonance Spectroscopy
Molecular Structure
Myristicaceae
Plant Extracts
Plant Leaves
Rights: fechado
Identifier DOI: 10.1002/ptr.2251
Address: http://www.ncbi.nlm.nih.gov/pubmed/17685388
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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