Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197689
Type: Artigo de periódico
Title: Oncocytic Metaplasia In Inflammatory Fibrous Hyperplasia: Histopathological And Immunohistochemical Analysis.
Author: Rangel, Ana Lúcia Carrinho Ayrosa
León, Jorge Esquiche
Jorge, Jacks
Lopes, Márcio Ajudarte
Vargas, Pablo Agustín
Abstract: Oncocytic metaplasia (OM) is not a well-known feature in inflammatory fibrous hyperplasia (IFH) lesions, although it may be common, as proposed in our previous study about this lesion. In the present paper, we assessed the histopathological and immunohistochemical features of 18 cases of IFH containing OM areas. All the samples were examined on haematoxylin and eosin stained sections and cytokeratins (AE1/AE3, 34betaE12, CK5, CK7, CK8, CK13, CK14 and CK19), CD15, CD20, CD68, CD45Ro, and LCA primary antibodies were used. The vast majority of IFH occurred in women (n=14) and the most common site of presentation was the buccal vestibule. Oncocytic and salivary duct cells showed uniform immunoreactivity for AE1/AE3, CK7, CK8 and CK19. CD45Ro+ T-lymphocytes were the most common inflammatory cells surrounding the OM areas followed by CD20+ B-lymphocytes. These findings suggest that oncocytic cells present in IFH might develop from salivary duct epithelium, and T-lymphocytes might play an important role in its etiopathogenesis.
Subject: Aged
Aged, 80 And Over
Female
Fibrosis
Humans
Hyperplasia
Immunohistochemistry
Inflammation
Male
Metaplasia
Middle Aged
Mouth Mucosa
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/18305433
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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