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Type: Artigo de periódico
Title: Mice Lacking The Extracellular Matrix Protein Magp1 Display Delayed Thrombotic Occlusion Following Vessel Injury.
Author: Werneck, Claudio C
Vicente, Cristina P
Weinberg, Justin S
Shifren, Adrian
Pierce, Richard A
Broekelmann, Thomas J
Tollefsen, Douglas M
Mecham, Robert P
Abstract: Mice lacking the extracellular matrix protein microfibril-associated glycoprotein-1 (MAGP1) display delayed thrombotic occlusion of the carotid artery following injury as well as prolonged bleeding from a tail vein incision. Normal occlusion times were restored when recombinant MAGP1 was infused into deficient animals prior to vessel wounding. Blood coagulation was normal in these animals as assessed by activated partial thromboplastin time and prothrombin time. Platelet number was lower in MAGP1-deficient mice, but the platelets showed normal aggregation properties in response to various agonists. MAGP1 was not found in normal platelets or in the plasma of wild-type mice. In ligand blot assays, MAGP1 bound to fibronectin, fibrinogen, and von Willebrand factor, but von Willebrand factor was the only protein of the 3 that bound to MAGP1 in surface plasmon resonance studies. These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis.
Subject: Animals
Bleeding Time
Blood Coagulation
Blood Platelets
Blood Pressure
Carotid Arteries
Contractile Proteins
Extracellular Matrix Proteins
Mice, Inbred C57bl
Platelet Function Tests
Protein Binding
Recombinant Proteins
Surface Plasmon Resonance
Von Willebrand Factor
Citation: Blood. v. 111, n. 8, p. 4137-44, 2008-Apr.
Rights: fechado
Identifier DOI: 10.1182/blood-2007-07-101733
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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