Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197661
Type: Artigo de periódico
Title: The Relationship Between Abo Groups And Subgroups, Factor Viii And Von Willebrand Factor.
Author: Sousa, Norma Cristina
Anicchino-Bizzacchi, Joyce Maria
Locatelli, Maria Fátima
Castro, Vagner
Barjas-Castro, Maria Lourdes
Abstract: The aim of this study was to correlate ABO groups with plasma levels of factor VIII (FVIII), von Willebrand factor (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological and molecular tests defined blood groups from 114 donors (10 AA, 10 BB, 10 AB, 10 AO1, 10 BO1,16 O1O1, 20 A2O1, 20 A2B, 4 A3O1, 3 AxO1, and 1 BelO1). The levels of VWF:Ag, FVIII and VWF:RCo observed in rare subgroups (A3O1, AxO1, BelO1) were similar to the values found in the O1O1 group. However, levels of these factors were significantly higher in A2O1 donors than in O1O1 donors (VWF:Ag p=0.01; FVIII p=0.04; VWF:RCo p<0.001). Strong correlations were demonstrated between plasma levels of VWF:Ag and FVIII (R=0.77; p=0.001) and between VWF:Ag and VWF:RCo (R=0.75; p=0.001).
Subject: Abo Blood-group System
Adam Proteins
Adolescent
Adult
Alleles
Carbohydrates
Factor Viii
Heterozygote
Humans
Male
Phenotype
Thrombophilia
Von Willebrand Diseases
Von Willebrand Factor
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/17296574
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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