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Type: | Artigo de periódico |
Title: | 5-ht Acts On Nociceptive Primary Afferents Through An Indirect Mechanism To Induce Hyperalgesia In The Subcutaneous Tissue. |
Author: | Oliveira, M C G Pelegrini-da-Silva, A Parada, C A Tambeli, C H |
Abstract: | We have recently demonstrated that s.c.-injected 5-hydroxytryptamine (5-HT) induces nociception by an indirect action on the primary afferent nociceptor in addition to its previously described direct action. Although the mechanisms mediating hyperalgesia can be quite separate and distinct from those mediating nociception, the aim of this study was to test the hypothesis that 5-HT induces mechanical hyperalgesia by mechanisms similar to those mediating nociception. s.c. injection of 5-HT induced a dose-dependent mechanical hyperalgesia measured by the mechanical paw withdrawal nociceptive threshold test in the rat. 5-HT-induced hyperalgesia was significantly reduced by local blockade of the 5-HT(3) receptor by tropisetron, by the nonspecific selectin inhibitor fucoidan, by the cyclooxygenase inhibitor indomethacin, by guanethidine depletion of norepinephrine in the sympathetic terminals, and by local blockade of the beta(1)- or beta(2)-adrenergic receptor by atenolol or ICI 118,551, respectively. Taken together, these findings indicate that like nociception, hyperalgesia induced by the injection of 5-HT in the s.c. tissue is also mediated by an indirect action of 5-HT on the primary afferent nociceptor. This indirect hyperalgesic action of 5-HT is mediated by a combination of mechanisms involved in inflammation such as neutrophil migration and the local release of prostaglandin and norepinephrine. However, in contrast to nociception, hyperalgesia induced by 5-HT in the s.c. tissue is mediated by a norepinephrine-dependent mechanism that involves the activation of peripheral beta(2) adrenoceptors. |
Subject: | Adrenergic Beta-2 Receptor Agonists Adrenergic Beta-2 Receptor Antagonists Adrenergic Beta-antagonists Afferent Pathways Animals Chemotaxis, Leukocyte Cyclooxygenase Inhibitors Dose-response Relationship, Drug Hyperalgesia Male Nociceptors Norepinephrine Pain Measurement Pain Threshold Prostaglandins Rats Rats, Wistar Receptors, Adrenergic, Beta-2 Receptors, Serotonin, 5-ht3 Selectins Sensory Receptor Cells Serotonin Serotonin 5-ht3 Receptor Antagonists Serotonin Antagonists Skin Sympathetic Fibers, Postganglionic |
Citation: | Neuroscience. v. 145, n. 2, p. 708-14, 2007-Mar. |
Rights: | fechado |
Identifier DOI: | 10.1016/j.neuroscience.2006.12.021 |
Address: | http://www.ncbi.nlm.nih.gov/pubmed/17257768 |
Date Issue: | 2007 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
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pmed_17257768.pdf | 463.14 kB | Adobe PDF | View/Open |
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