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Type: Artigo de periódico
Title: Absence Of Classical Heat Shock Response In The Citrus Pathogen Xylella Fastidiosa.
Author: Martins-de-Souza, Daniel
Martins, Daniel
Astua-Monge, Gustavo
Coletta-Filho, Helvécio Della
Winck, Flavia Vischi
Baldasso, Paulo Aparecido
de Oliveira, Bruno Menezes
Marangoni, Sérgio
Machado, Marcos Antônio
Novello, José Camillo
Smolka, Marcus Bustamante
Abstract: The fastidious bacterium Xylella fastidiosa is associated with important crop diseases worldwide. We have recently shown that X. fastidiosa is a peculiar organism having unusually low values of gene codon bias throughout its genome and, unexpectedly, in the group of the most abundant proteins. Here, we hypothesized that the lack of codon usage optimization in X. fastidiosa would incapacitate this organism to undergo quick and massive changes in protein expression as occurs in a classical stress response. Proteomic analysis of the response to heat stress in X. fastidiosa revealed that no changes in protein expression can be detected. Moreover, stress-inducible proteins identified in the closely related citrus pathogen Xanthomonas axonopodis pv citri were found to be constitutively expressed in X. fastidiosa. These proteins have extremely high codon bias values in the X. citri and other well-studied organisms, but low values in X. fastidiosa. Because biased codon usage is well known to correlate to the rate of protein synthesis, we speculate that the peculiar codon bias distribution in X. fastidiosa is related to the absence of a classical stress response, and, probably, alternative strategies for survival of X. fastidiosa under stressfull conditions.
Subject: Bacterial Proteins
Chaperonin 10
Gene Expression Regulation, Bacterial
Heat-shock Proteins
Heat-shock Response
Plant Diseases
Rights: fechado
Identifier DOI: 10.1007/s00284-006-0215-2
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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