Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197613
Type: Artigo de periódico
Title: Experimental Alcoholism And Pathogenesis Of Prostatic Diseases In Uchb Rats.
Author: Cândido, Eduardo Marcelo
Carvalho, César Alexandre Fabrega
Martinez, Francisco Eduardo
Cagnon, Valéria Helena Alves
Abstract: Previous studies have shown that long-term alcohol treatment has negative effects on prostatic stromal-epithelial interaction. Thus, the aim of the present study was to analyze the histochemical, immunohistochemical and ultrastructural alterations that occur in the prostatic stroma and epithelium of rats submitted to chronic alcohol ingestion and alcohol abstinence, as well as to establish the relationship between these changes and prostatic diseases. Thirty male rats (10 Wistar and 20 UChB rats) were divided into three experimental groups: the control group received tap water, the alcoholic group received ethanol diluted to 10 degrees G.L. for 150 days, and the abstinent group received the same liquid diet as the alcoholic group up to 120 days of treatment and only tap water for 30 days thereafter. At the end of treatment, all animals were sacrificed and the ventral lobe of the prostate was removed and processed for histochemical, immunohistochemical and ultrastructural analyses. In addition, plasma testosterone levels were measured. The results showed prostatic intraepithelial neoplasia, infolding of the epithelium towards the stroma, stromal hypertrophy and the presence of inflammatory cells in alcoholic animals. In the abstinent group, alterations were noted mainly in the stromal area. In conclusion, ethanol triggers alterations in prostatic epithelial and stromal compartments, affecting the stromal microenvironment and predisposing the organ to pathological processes.
Subject: Alcoholism
Animals
Body Weight
Disease Models, Animal
Male
Microscopy, Electron, Scanning
Nutritional Status
Prostate
Prostatic Diseases
Rats
Rats, Inbred Strains
Rats, Wistar
Rights: fechado
Identifier DOI: 10.1016/j.cellbi.2006.11.009
Address: http://www.ncbi.nlm.nih.gov/pubmed/17188526
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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